According to the article of Enrique Schisterman published in JAMA the 07/ 01/ 2020 and disclosed in #Drugs.com & #OKILAB

Male Fertility Supplements Fail to Deliver

Supplements containing zinc and folic acid don’t appear to boost male fertility

Despite marketing claims, these supplements don’t improve pregnancy rates, sperm counts or sperm function, researchers say.

The researchers recruited more than 2,300 U.S. couples planning to get fertility treatment. They randomly assigned the men to take a pill containing zinc and folic acid or a placebo.

Births didn’t differ between men who got the supplement and men who didn’t. Among men who took the supplement, there were 404 births, compared with 416 among men who took the placebo, the researchers reported.

Sperm health was also similar between the groups. But the proportion of broken DNA in the sperm was higher in the supplement group (30%) than in the placebo group (27%). Studies have linked a high rate of broken sperm DNA with infertility, the researchers noted.

Men who took the supplement also reported more abdominal discomfort, nausea and vomiting than men who took the placebo